Primary Familial Carpal Tunnel Syndrome with Long-term Follow-up: A Study of Two Families and Review of the Literature

Carpal tunnel syndrome (CTS) is the most common neuropathy of the upper extremity [1, 2]. When disease is bilateral and family history is positive, one should rule out hereditary neuropathies, inborn errors of metabolism such as mucopolysaccharidosis, and underlying systemic disorders such as endocrinopathies, renal disease, and amyloidosis (Table 1) [1-5]. The absence of more Sean R Cantwell1, Niles J Batdorf2, Julie E Adams3 and Steven L Moran3